Nanoparticles in Biomedical Imaging Emerging Technologies and Applications











Preface

Within a short time frame, diagnostic nanomedicine has emerged as a multidisciplinary

field that promises to deliver a more specific and sensitive detection of

early disease processes. Nanoparticles (particles measuring approximately 1–100

nm) allow incorporation of a high number of detectable tracers or molecules

through which they can amplify changes in signal intensity. This book contains 23

chapters dedicated to the use of nanoparticles in biomedical imaging, covering all

aspects including the chemistry of nanoparticle synthesis, the physics of contrast

and signal-generating mechanisms, the biological and pharmacokinetic profiles,

and their use in pre-clinical animal models as well as humans. Experts throughout

the world have made contributions for five major imaging modalities, namely the

use of nanoparticles in magnetic resonance imaging, nuclear medicine, ultrasound

imaging, computed tomography imaging, and optical imaging. We hope that this

book may form a foundation for further advances in the field of nanomedicine

and diagnostics.



Jeff W.M. Bulte and Michel M.J. Modo

Baltimore and London,

January 2007







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